产品详情
产品名称p504s Antibody
来源种属Mouse
克隆性Monoclonal
克隆号IHC504
应用IHC
种属反应性Human
配方Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
保存Store at 2-8C. Do not freeze.
应用详情
Recommended
working dilution range:1:100 - 1:200
产品描述
p504s, also known as α-methylacyl coenzyme A racemase (AMACR), is an enzyme localized in the peroxisome and mitochondria, which functions in -oxidation of branched chain fatty acids, as well as bile synthesis. AMACR has been clinically indicated as a tissue biomarker for prostate cancer and colorectal cancer, as well as high-grade prostatic intraepithelial neoplasia, a precursor lesion of prostate cancer. p504s overexpression has also been detected in a number of other cancers including ovarian, breast, bladder, lung, and renal cell carcinomas, lymphoma, and melanoma.
背景文献
Ferdinandusse S, et al. J Lipid Res. 2000; 41:1890-6.
Xu J, et al. Cancer Res. 2000; 60:1677-82.
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Luo J, et al. Cancer Res. 2002; 62:2220-6.
Zhou M, et al. Am J Surg Pathol. 2002; 26:926-31.
Wu CL, et al. Hum Pathol. 2004; 35:1008-13.