产品详情
产品名称SALL4 Antibody
来源种属Mouse
克隆性Monoclonal
克隆号IHC659
应用IHC
种属反应性Human
配方Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
保存Store at 2-8C. Do not freeze.
应用详情
Recommended
working dilution range:1:100 - 1:200
产品描述
Sal-Like Protein 4 (SALL4), is a zinc finger transcription factor found in germ cells and human blood progenitor cells, with functional involvement in modulating Oct-4 to maintain embryonic stem cell pluripotency. SALL4 is a useful marker for acute myeloid leukemia, B-cell acute lymphocytic leukemia, intratubular germ cell neoplasia, seminomas/dysgerminomas, and yolk sac tumors (both pediatric and postpubertal). Anti-SALL4 is used to detect embryonal carcinomas, hepatocellular carcinoma (HCC), gliomas, ovarian primitive germ-cell tumors, choriocarcinomas, spermatogonia, teratoma, gastric cancer, breast cancer, and lung cancer. Expression of SALL4 is often associated with poor prognosis in HCC, and with metastasis in endometrial cancer, colorectal carcinoma, and esophageal squamous cell carcinoma.
背景文献
Ma Y, et al. Blood. 2006; 108:2726-35.
de Celis JF, et al. Int J Dev Biol. 2009; 53:1385C98.
Kohlhase J, et al. Hum Mutat. 2005; 26:176C83.
Miettinen M, et al. Am J Surg Pathol. 2014; 38:410C20.
Zhang X, et al. Cancer Lett. 2015; 357:55C62.
Ueno S, et al. Exp Hematol. 2014; 42:307C16.
Cao D, et al. Am J Surg Pathol. 2009; 33:1065C77.
Zhang L, et al. Oncogene. 2014; 33:5491C500.
Kobayashi D, et al. Int J Oncol. 2011; 38:933C9.
Cui W, et. al. Mod Pathol. 2006; 19:1585-92.
Cao D, et al. Am J Surg Pathol. 2009; 33:894-904.
2-3 weeks
