Adducins are a family of cytoskeleton proteins encoded by three genes (a, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. a- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. a- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.

Pariser H, et al. Proc Natl Acad Sci USA 2005 Aug 30; 102(35): 12407-12
Tamaru S, et al. Biochem Biophys Res Commun 2005 Jul 01; 332(2): 347-51
Barkalow KL, et al. J Cell Biol 2003 May 12; 161(3): 557-70