Junctional Adhesion Molecule 1 Conjugated Antibody - SAB

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产品详情

产品名称Junctional Adhesion Molecule 1 Conjugated Antibody

来源种属Rabbit

克隆性Monoclonal

应用WB, IF

种属反应性Hu, Ms, Rt

免疫原描述recombinant protein

标记Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750

激发/发射波长AF350: 346nm/442nm
AF405: 401nm/421nm
AF488: 493nm/519nm
AF555: 555nm/565nm
AF594: 591nm/614nm
AF647: 651nm/667nm
AF680: 679nm/702nm
AF750: 749nm/775nm

别名CD 321 antibody
CD321 antibody
CD321 antigen antibody
ESTM33 antibody
F11 receptor antibody
F11R antibody
JAM 1 antibody
JAM A antibody
JAM antibody
JAM-1 antibody
JAM-A antibody
JAM1 antibody
JAM1_HUMAN antibody
JAMA antibody
JCAM antibody
Jcam1 antibody
Junction adhesion molecule 1 antibody
Junction adhesion molecule, mouse, homolog of antibody
Junctional adhesion molecule 1 antibody
Junctional adhesion molecule A antibody
KAT antibody
Ly106 antibody
PAM 1 antibody
PAM-1 antibody
PAM1 antibody
Platelet adhesion molecule 1 antibody
Platelet adhesion molecule antibody
Platelet F11 receptor antibody
PRO301 antibody
UNQ264 antibody

数据库入口号Swiss-Prot#:Q9Y624

计算分子量33 kDa

配方0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

保存Store at 4˚C in dark for 6 months

应用详情

WB: 1:50-1:200
IF:1:50-1:200

背景

Junctional adhesion molecule (JAM) is a member of the immunoglobulin superfamily expressed in tight junctions of epithelial cells and endothelial cells. It is implicated in transendothelial migration of leukocytes. JAM is constitutively expressed on circulating monocytes, neutrophils, lymphocyte subsets and platelets. The JAM family consists of JAM-A, JAM-B and JAM-C, alternatively designated JAM-1, JAM-2 and JAM-3, respectively. JAM-A localizes with F-Actin at the cell-cell contacts and at the membrane ruffles. It is involved in cell to cell adhesion through homophilic interactions and plays a role in the organization of tight junctions and modulation of leukocyte extravasation. JAM-B interacts with discrete subsets of PBLs, suggesting that it may play a role in lymphocyte trafficking. JAM-B and JAM-C proteins are binding partners; JAM-C may be a functional JAM-B receptor. Specifically, JAM-B adheres to T cells through heterotypic interactions with JAM-C. The JAM-B/JAM-C interaction my play a role in T, NK and dendritic cellular inflammation.

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应用

WB免疫印迹
IHC免疫组化
IF免疫荧光
ICC免疫细胞化学
FC流式细胞
IP免疫沉淀
E酶联免疫吸附法
DB免疫斑点法
ChIP染色质免疫沉淀
GICA胶体金免疫层析法
NC阴性对照

种属反应性

Hu人
Ms小鼠
Rt大鼠
Dm果蝇
C线虫
Mk猴
Rb兔
B牛
D狗
P猪
Hm仓鼠
ChHm中国仓鼠
Chk鸡

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