Vitamin D Receptor Conjugated Antibody - SAB

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产品详情

产品名称Vitamin D Receptor Conjugated Antibody

来源种属Rabbit

克隆性Monoclonal

应用WB, IF, FC

种属反应性Hu, Ms, Rt

免疫原描述recombinant protein

标记Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750

激发/发射波长AF350: 346nm/442nm
AF405: 401nm/421nm
AF488: 493nm/519nm
AF555: 555nm/565nm
AF594: 591nm/614nm
AF647: 651nm/667nm
AF680: 679nm/702nm
AF750: 749nm/775nm

别名1 25 dihydroxyvitamin D3 receptor antibody
1 antibody
1,25 dihydroxyvitamin D3 receptor antibody
1,25-@dihydroxyvitamin D3 receptor antibody
25-dihydroxyvitamin D3 receptor antibody
Member 1 antibody
NR1I1 antibody
Nuclear receptor subfamily 1 group I member 1 antibody
PPP1R163 antibody
Protein phosphatase 1, regulatory subunit 163 antibody
VDR antibody
VDR_HUMAN antibody
Vitamin D (1,25- dihydroxyvitamin D3) receptor antibody
Vitamin D hormone receptor antibody
Vitamin D nuclear receptor variant 1 antibody
Vitamin D receptor antibody
Vitamin D3 receptor antibody

数据库入口号Swiss-Prot#:P11473

计算分子量48 kDa

配方0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

保存Store at 4˚C in dark for 6 months

应用详情

WB: 1:50-1:200
IF:1:50-1:200
FC: 1:50-1:200

背景

he active metabolite of vitamin D modulates the expression of a wide variety of genes in a developmentally specific manner. This secosteroid hormone can up- or downregulate the expression of genes involved in a diverse array of responses such as proliferation, differentiation and calcium homeostasis. 1,25-(OH)2-vitamin D3 exerts its effects through interaction with the vitamin D receptor (VDR), a member of the superfamily of hormone-activated nuclear receptors. In its ligand-bound state, the VDR forms heterodimers with the 9-cis retinoic acid receptor, RXR, and affects gene expression by binding specific DNA sequences known as hormone response elements, or HREs. In addition to regulating the above-mentioned cellular responses, 1,25-(OH)2-vitamin D3 exhibits antiproliferative properties in osteosarcoma, melanoma, colon carcinoma and breast carcinoma cells.

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操作手册

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应用

WB免疫印迹
IHC免疫组化
IF免疫荧光
ICC免疫细胞化学
FC流式细胞
IP免疫沉淀
E酶联免疫吸附法
DB免疫斑点法
ChIP染色质免疫沉淀
GICA胶体金免疫层析法
NC阴性对照

种属反应性

Hu人
Ms小鼠
Rt大鼠
Dm果蝇
C线虫
Mk猴
Rb兔
B牛
D狗
P猪
Hm仓鼠
ChHm中国仓鼠
Chk鸡

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