JAB1 Conjugated Antibody - SAB | Signalway Antibody

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产品详情

产品名称JAB1 Conjugated Antibody

来源种属Rabbit

克隆性Monoclonal

应用WB, IF

种属反应性Hu, Ms, Rt

免疫原描述Recombinant protein

标记Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750

激发/发射波长AF350: 346nm/442nm
AF405: 401nm/421nm
AF488: 493nm/519nm
AF555: 555nm/565nm
AF594: 591nm/614nm
AF647: 651nm/667nm
AF680: 679nm/702nm
AF750: 749nm/775nm

别名38 kDa Mov34 homolog antibody
COP9 (constitutive photomorphogenic) homolog subunit 5 antibody
COP9 constitutive photomorphogenic homolog subunit 5 antibody
COP9 signalosome complex subunit 5 antibody
COP9 signalosome subunit 5 antibody
Cop9 subunit 5 antibody
COPS 5 antibody
cops5 antibody
CSN 5 antibody
CSN5 antibody
CSN5_HUMAN antibody
JAB 1 antibody
Jun activation domain binding protein 1 antibody
Jun activation domain binding protein antibody
Jun activation domain-binding protein 1 antibody
MGC3149 antibody
MOV 34 antibody
MOV34 antibody
MOV34 family, 38-KD member antibody
SGN 5 antibody
SGN5 antibody
Signalosome subunit 5 antibody

数据库入口号Swiss-Prot#:Q92905

计算分子量37 kDa, additional band 100 kDa.

配方0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

保存Store at 4˚C in dark for 6 months

应用详情

WB: 1:50-1:200
IF:1:50-1:200

背景

Genes belonging to the Jun and Fos oncogene families encode nuclear proteins that are found to be associated with a number of transcriptional complexes. The c-Jun protein is a major component of the transcription factor AP-1, originally shown to mediate phorbol ester tumor promoter (TPA)-induced expression of responsive genes through the TPA-response element (TRE). The Jun proteins form homo- and heterodimers which bind the TRE, but the Fos proteins are active only as heterodimers with any of the Jun proteins. Fos/Jun heterodimers have a much higher affinity for the TRE than Jun homodimers. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. The coactivator of Jun, designated JAB1 (for Jun-activation domain-binding protein), interacts with c-Jun and Jun D, but not with Jun B or v-Jun. This interaction enhances the transactivating ability of Jun proteins by stabilizing their binding to the TRE. The gene encoding JAB1 maps to human chromosome 8q12.3.

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应用

WB免疫印迹
IHC免疫组化
IF免疫荧光
ICC免疫细胞化学
FC流式细胞
IP免疫沉淀
E酶联免疫吸附法
DB免疫斑点法
ChIP染色质免疫沉淀
GICA胶体金免疫层析法
NC阴性对照

种属反应性

Hu人
Ms小鼠
Rt大鼠
Dm果蝇
C线虫
Mk猴
Rb兔
B牛
D狗
P猪
Hm仓鼠
ChHm中国仓鼠
Chk鸡

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