CD146 Conjugated Antibody - SAB | Signalway Antibody

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产品详情

产品名称CD146 Conjugated Antibody

来源种属Rabbit

克隆性Monoclonal

应用WB, IF, FC

种属反应性Hu, Ms, Rt

免疫原描述Recombinant protein

标记Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750

激发/发射波长AF350: 346nm/442nm
AF405: 401nm/421nm
AF488: 493nm/519nm
AF555: 555nm/565nm
AF594: 591nm/614nm
AF647: 651nm/667nm
AF680: 679nm/702nm
AF750: 749nm/775nm

别名A32 antigen antibody
CD 146 antibody
CD146 antibody
CD146 antigen antibody
Cell surface glycoprotein MUC18 antibody
Cell surface glycoprotein P1H12 antibody
Gicerin antibody
Mcam antibody
Melanoma adhesion molecule antibody
Melanoma associated antigen A32 antibody
Melanoma associated antigen MUC18 antibody
Melanoma associated glycoprotein MUC18 antibody
Melanoma cell adhesion molecule antibody
Melanoma-associated antigen A32 antibody
Melanoma-associated antigen MUC18 antibody
MelCAM antibody
MUC 18 antibody
MUC18 antibody
MUC18_HUMAN antibody
S endo 1 antibody
S endo 1 endothelial associated antigen antibody
S-endo 1 endothelial-associated antigen antibody

数据库入口号Swiss-Prot#:P43121

计算分子量72 kDa

配方0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

保存Store at 4˚C in dark for 6 months

应用详情

WB: 1:50-1:200
IF:1:50-1:200
FC: 1:50-1:200

背景

The tumorigenic and metastatic phenotype of melanoma cells correlates well with an increased expression of cell-cell and cell-matrix adhesion receptors. The human Mel-CAM gene encodes a transmembrane glycoprotein, also designated MCAM, MUC18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. The deduced human sequence of 603 amino acids consists of a signal peptide, five immunoglobulin-like domains, a transmembrane region and a short cytoplasmic tail. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human mela-nomas and correlates well with development of metastatic disease. Mel-CAM activation initiates an outside-in signaling pathway that involves the protein tyrosine kinases Fyn, FAK and paxillin. Mel-CAM influences the dynamics of Actin cytoskeleton rearrangement and is essential for the maintenance of thymic architecture and function.

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WB免疫印迹
IHC免疫组化
IF免疫荧光
ICC免疫细胞化学
FC流式细胞
IP免疫沉淀
E酶联免疫吸附法
DB免疫斑点法
ChIP染色质免疫沉淀
GICA胶体金免疫层析法
NC阴性对照

种属反应性

Hu人
Ms小鼠
Rt大鼠
Dm果蝇
C线虫
Mk猴
Rb兔
B牛
D狗
P猪
Hm仓鼠
ChHm中国仓鼠
Chk鸡

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