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位置: 首页 > 标记抗体 > WNK1 Conjugated Antibody

WNK1 Conjugated Antibody#C49911

是否有货: 1-2 weeks
产品总价:
产品详情

产品名称WNK1 Conjugated Antibody

来源种属Rabbit

克隆性Monoclonal

应用WB, IF

种属反应性Hu, Ms, Rt

免疫原描述Synthetic peptide within Human WNK1 aa 100-200 (Cysteine residue).

标记Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750

激发/发射波长AF350: 346nm/442nm
AF405: 401nm/421nm
AF488: 493nm/519nm
AF555: 555nm/565nm
AF594: 591nm/614nm
AF647: 651nm/667nm
AF680: 679nm/702nm
AF750: 749nm/775nm

别名Erythrocyte 65 kDa protein antibody
HSAN2 antibody
HSN2 antibody
hWNK1 antibody
KDP antibody
KIAA0344 antibody
Kinase deficient protein antibody
MGC163339 antibody
MGC163341 antibody
p65 antibody
PPP1R167 antibody
PRKWNK1 antibody
Prostate derived sterile 20 like kinase antibody
Protein kinase lysine deficient 1 antibody
Protein kinase lysine-deficient 1 antibody
Protein kinase with no lysine 1 antibody
Protein phosphatase 1, regulatory subunit 167 antibody
PSK antibody
Serine/threonine protein kinase WNK1 1 antibody
Serine/threonine protein kinase WNK1 2 antibody
Serine/threonine protein kinase WNK1 antibody
Serine/threonine-protein kinase WNK1 antibody
With no K antibody
WNK lysine deficient protein kinase 1 antibody
WNK lysine deficient protein kinase 1 isoform antibody
WNK1 antibody
WNK1_HUMAN antibody

数据库入口号Swiss-Prot#:Q9H4A3

计算分子量250/300 kDa

配方0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

保存Store at 4˚C in dark for 6 months

应用详情
WB: 1:50-1:200
IF:1:50-1:200
背景
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

联系我们

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Phone :

400-9961-933
025-58868422

Email Address

techcn@signalwayantibody.com