ORP150 Conjugated Antibody - SAB

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产品详情

产品名称ORP150 Conjugated Antibody

来源种属Rabbit

克隆性Monoclonal

应用WB, IF, FC

种属反应性Hu, Ms, Rt

免疫原描述Recombinant protein within human ORP150 aa 800-950.

标记Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750

激发/发射波长AF350: 346nm/442nm
AF405: 401nm/421nm
AF488: 493nm/519nm
AF555: 555nm/565nm
AF594: 591nm/614nm
AF647: 651nm/667nm
AF680: 679nm/702nm
AF750: 749nm/775nm

别名150 kDa oxygen regulated protein antibody
150 kDa oxygen-regulated protein antibody
170 kDa glucose regulated protein antibody
170 kDa glucose-regulated protein antibody
DKFZp686N08236 antibody
FLJ94899 antibody
FLJ97572 antibody
glucose regulated protein 170 antibody
Grp 170 antibody
GRP-170 antibody
Grp170 antibody
HSP 12A antibody
HSP12A antibody
Hyou1 antibody
HYOU1_HUMAN antibody
Hypoxia up regulated 1 antibody
hypoxia up-regulated 1 precursor antibody
Hypoxia up-regulated protein 1 antibody
Hypoxia upregulated 1 antibody
Orp 150 antibody
ORP-150 antibody
Orp150 antibody
oxygen regulated protein (150kD) antibody

数据库入口号Swiss-Prot#:Q9Y4L1

计算分子量111 kDa

配方0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

保存Store at 4˚C in dark for 6 months

应用详情

WB: 1:50-1:200
IF:1:50-1:200
FC: 1:50-1:200

背景

ORP150, also known as HYOU1 (hypoxia upregulated 1), is a 999 amino acid protein that localizes to the lumen of the endoplasmic reticulum (ER) and is a member of the heat shock protein 70 (HSP 70) family. ORP150 is highly expressed in tissues that have well-developed ERs and a large number of secretory proteins (such as liver and pancreas). It is expressed at lower levels in kidney and brain, and plays an essential role in cytoprotective cellular responses to hypoxia (oxygen deprivation). Specifically, ORP150 participates in protein folding and secretion in the ER and functions to protect cells from hypoxia-induced apoptosis, thereby playing a crucial role in cell survival. ORP150 expression is upregulated in a variety of tumors, such as breast cancer, suggesting an important role in tumorigenesis. The gene encoding ORP150 has two translation initiation sites, resulting in a truncated transcript that lacks an ER signal peptide, but is thought to function as a housekeeping protein in the cytoplasm.

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应用

WB免疫印迹
IHC免疫组化
IF免疫荧光
ICC免疫细胞化学
FC流式细胞
IP免疫沉淀
E酶联免疫吸附法
DB免疫斑点法
ChIP染色质免疫沉淀
GICA胶体金免疫层析法
NC阴性对照

种属反应性

Hu人
Ms小鼠
Rt大鼠
Dm果蝇
C线虫
Mk猴
Rb兔
B牛
D狗
P猪
Hm仓鼠
ChHm中国仓鼠
Chk鸡

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