产品详情
产品名称SIRP alpha Antibody
来源种属Rabbit
克隆性Polyclonal
纯化DEAE purified
应用ELISA WB ICC
种属反应性Hu Ms Rt
特异性Recognizes SIRP alpha 1, 2 and 3.
免疫原类型Peptide
免疫原描述Raised against a peptide corresponding to amino acids near the carboxy terminus of human SIRP alpha 1. The sequences of the immunogenic peptide differ from those of mouse, rat and bovine by one amino acid.
基因/蛋白名称SIRP alpha
别名SHPS-1, SIRPa
数据库入口号NP_542970
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Predicted MW: 75 - 110 kd
背景
Protein tyrosine phosphatases (PTPases) SHP-1 and SHP-2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPalpha, SHPS-1, MyD-1, BIT and p84. SIRPalpha is a new gene family containing at least fifteen members. SIRPalpha is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP-2. SIRPalpha has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes.
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