产品详情
产品名称DR3 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化DEAE purified
应用ELISA WB
种属反应性Hu Ms
特异性DR3 has no cross reaction to other death receptors.
免疫原类型Peptide
免疫原描述Raised against a peptide corresponding to amino acids 25 to 40 of human DR3 precusor.
基因/蛋白名称DR3
别名Wsl-1, Apo-3
数据库入口号AAQ88676
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Predicted MW: 59 kd
背景
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD1-5. The ligand for this novel death receptor has been defined as TWEAK, also termed Apo3L. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-κB activation.
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