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EXOSC4 antibody#31991

EXOSC4 antibody
EXOSC4 antibody
是否有货: Yes
产品总价:
产品详情

产品名称EXOSC4 antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antigen affinity purification

应用WB, IHC

种属反应性Hu, Ms

免疫原描述Fusion protein of human EXOSC4

基因/蛋白名称EXOSC4

别名SKI6; p12A; RRP41; Ski6p; RRP41A; Rrp41p; hRrp41p

数据库入口号NCBI Protein#:BC002777

UniprotQ9NPD3

Gene ID54512

计算分子量26 kDa

浓度0.8mg/ml

配方pH7.4 PBS, 0.05% NaN3, 40% Glycerol

保存Store at -20˚C/1 year

应用详情
WB dilution:1:500-1:2000
IHC dilution:1:50-1:200
Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-7: Human fetal liver tissue, RAW264.7, PC-3, 293T, LO2, Hela and Jurkat cell lysates, Primary antibody:EXOSC4 Antibody at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 20 seconds
The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (EXOSC4 Antibody) at dilution 1/50.
背景
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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