产品详情
产品名称DcR3 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Ion exchange chromatography purified
应用ELISA WB IHC
种属反应性Hu Ms Rt
免疫原类型Peptide
免疫原描述Raised against a peptide corresponding to amino acids near the amino terminus of human DcR3 precursor.
基因/蛋白名称DcR3
别名DcR3, DCR3, TR6
数据库入口号AF104419
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Predicted MW: 33 kd
背景
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and function as cell death receptors. Two decoy receptors, DcR1 and DcR2, were recently identified to compete with DR4 and DR5 for their ligand TRAIL binding. A novel decoy receptor was more recently discovered and designated DcR3 and TR6, respectively,. Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL and LIGHT induced apoptosis. DcR3 transcript is expressed in a number of lung and colon carcinomas and in some normal tissues.
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