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AIF Antibody#24114

AIF Antibody
AIF Antibody
是否有货: 有货
产品总价:
产品详情

产品名称AIF Antibody

来源种属Rabbit

克隆性Polyclonal

纯化AIF Antibody is DEAE purified.

应用ELISA WB ICC

种属反应性Hu Ms Rt

免疫原类型Peptide

免疫原描述Raised against a peptide corresponding to amino acids 593 to 606 of human AIF. This sequence is identical to those of mouse and rat AIF.

基因/蛋白名称AIF

数据库入口号O95381

浓度1mg/ml

配方Supplied in PBS containing 0.02% sodium azide.

保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

应用详情
Predicted MW: 67 kd
Western blot analysis of AIF in K562 with AIF antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL.
Immunocytochemistry of AIF in K562 cells with AIF antibody at 5 ug/mL.
背景
Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins. A novel gene, the product of which causes chromatin condensation and DNA fragmentation, was recently identified, cloned, and designated apoptosis inducing factor (AIF). Like the critical molecules, cytochrome c and caspase-9, in apoptosis, AIF localizes in mitochondria. AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIF induces chromatin condensation and DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection. AIF is highly conserved between human and mouse and widely expressed.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

联系我们

Location :

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Phone :

400-9961-933
025-58868422

Email Address

techcn@signalwayantibody.com