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Smac Antibody#24133

Smac Antibody
Smac Antibody
是否有货: 有货
产品总价:
产品详情

产品名称Smac Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Smac Antibody is DEAE purified.

应用ELISA WB IHC

种属反应性Hu Ms Rt

免疫原类型Peptide

免疫原描述Raised against a peptide corresponding to amino acids 225 to 239 of human Smac/DIABLO.

基因/蛋白名称Smac

别名DIABLO

数据库入口号AAF87716

浓度1mg/ml

配方Supplied in PBS containing 0.02% sodium azide.

保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

应用详情
Predicted MW: 25 kd
Western blot analysis of Smac in human heart tissue lysate in the absence (A) or presence (B) of blocking peptide (2409P) with Smac antibody at 1 ug /ml.
Immunohistochemistry of Smac/DIABLO in human ovary tissue with Smac antibody at 5 ug/mL.
背景
The inhibitor of apoptosis proteins (IAPs) regulate programmed cell death by inhibiting members of the caspase family of enzymes. A novel mammalian protein that binds to IAPs and neutralizes the inhibitory effect of IAPs on caspases was recently identified and designated Smac/DIABLO. Smac/DIABLO is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates cytochrome c/Apaf-1/capase-9 pathway. Analysis of the structural basis of Smac/DIABLO reveals that the N-terminal amino acids are required for binding of Smac/DIABLO to IAPs and activation of caspases. Smac/DIABLO is expressed in a variety of human and mouse tissues.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

联系我们

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400-9961-933
025-58868422

Email Address

techcn@signalwayantibody.com