产品详情
产品名称CARD9 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化CARD9 Antibody is DEAE purified.
应用ELISA WB ICC
种属反应性Hu
免疫原类型Peptide
免疫原描述Raised against a synthetic peptide corresponding to amino acids 521 to 536 of human CARD9. The sequence is different from that of rat origin by two amino acids.
基因/蛋白名称CARD9
数据库入口号AF311287
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Predicted MW: 59 kd
背景
Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, BCL-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD9, which interacts with the CARD activation domain of BCL-10. CARD9 associates with BCL-10 and forms a complex within cells. CARD9 induces apoptosis and activates NF-κB. CARD9 is an upstream activator of BCL-10 and NF-κB signaling.
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