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位置: 首页 > 抗体 > NR3C1 Rabbit Polyclonal Antibody

NR3C1 Rabbit Polyclonal Antibody#53694

NR3C1 Rabbit Polyclonal Antibody
NR3C1 Rabbit Polyclonal Antibody
是否有货: Yes
产品总价:
产品详情

产品名称NR3C1 Rabbit Polyclonal Antibody

来源种属Rabbit

克隆性Polyclonal

亚型IgG

纯化Affinity purification

应用WB,IF

种属反应性Human

免疫原描述Recombinant fusion protein of human NR3C1 (NP_001191194.1).

别名GCCR;GCR;GCRST;GR;GRL;NR3C1

数据库入口号Swiss Prot:P04150
GeneID:2908

UniprotP04150

计算分子量49-85kDa

实际分子量105kDa

配方Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

保存Store at -20˚C. Avoid freeze / thaw cycles.

应用详情
WB 1:500 - 1:2000
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using NR3C1 at 1:1000 dilution.
Immunofluorescence analysis of U2OS cells using NR3C1 at dilution of 1:100. Blue: DAPI for nuclear staining.
背景
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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