免费电话:400-9961-933
邮箱:techcn@signalwayantibody.com
欢迎光临本站
登录 注册 English
位置: 首页 > 抗体 > Caspase-12 Antibody(Large)

Caspase-12 Antibody(Large)#24208

Caspase-12 Antibody(Large)
Caspase-12 Antibody(Large)
是否有货: 有货
产品总价:
产品详情

产品名称Caspase-12 Antibody(Large)

来源种属Rabbit

克隆性Polyclonal

纯化Affinity chromatography purified via peptide column

应用ELISA WB IHC

种属反应性Hu Ms Rt

免疫原类型Peptide

免疫原描述Raised against a synthetic peptide corresponding to amino acids within the large cleavage product of murine caspase-12.

基因/蛋白名称Caspase-12 (Large)

别名Caspase-12 (large), Casp-12 (lrg)

数据库入口号CAA73532

浓度1mg/ml

配方Supplied in PBS containing 0.02% sodium azide.

保存Caspase-12 antibody (Large) can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western blot analysis of caspase-12 in human heart lysate with caspase-12 antibody (large) at 0.5 (lane A), 1 (lane B), and 2 ug/mL (lane C), respectively.
Immunohistochemical staining of human heart tissue using caspase-12 antibody (large) at 2 ug/mL.
背景
Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

如果您使用该产品24208发表了文章,请通知我们,让我们可以引用您的文献。

5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

联系我们

Location :

南京市高新开发区星火路10号人才大厦C座

Phone :

400-9961-933
025-58868422

Email Address

techcn@signalwayantibody.com