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NOTCH1 Rabbit Polyclonal Antibody#54516

NOTCH1 Rabbit Polyclonal Antibody
NOTCH1 Rabbit Polyclonal Antibody
NOTCH1 Rabbit Polyclonal Antibody
NOTCH1 Rabbit Polyclonal Antibody
是否有货: Yes
产品总价:
产品详情

产品名称NOTCH1 Rabbit Polyclonal Antibody

来源种属Rabbit

克隆性Polyclonal

亚型IgG

纯化Affinity purification

应用WB,IHC

种属反应性Human,Mouse,Rat

免疫原描述Recombinant protein of human NOTCH1.

别名AOS5;AOVD1;TAN1;hN1;NOTCH1;Activated NOTCH1;notch 1

数据库入口号Swiss Prot:P46531
GeneID:4851

UniprotP46531

计算分子量272kDa

实际分子量115kDa

配方Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

保存Store at -20˚C. Avoid freeze / thaw cycles.

应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
Immunohistochemistry of paraffin-embedded Rat testis using NOTCH1 at dilution of 1:100 (20x lens).
Immunohistochemistry of paraffin-embedded Human colon using NOTCH1 at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded Mouse testis using NOTCH1 at dilution of 1:100 (20x lens).
Western blot analysis of extracts of various cell lines, using NOTCH1 at 1:1000 dilution.
背景
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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025-58868422

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