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Mcl-1 Antibody#24299

Mcl-1 Antibody
Mcl-1 Antibody
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产品总价:
产品详情

产品名称Mcl-1 Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Ion exchange chromatography purified

应用ELISA WB ICC

种属反应性Hu

特异性Detects both isoforms of Mcl-1

免疫原类型Peptide

免疫原描述Raised against a peptide corresponding to 16 amino acids near the amino-terminus of human Mcl-1.

基因/蛋白名称Mcl-1

别名Myeloid cell leukemia 1

数据库入口号NP_068779

浓度1mg/ml

配方Supplied in PBS containing 0.02% sodium azide.

保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western blot analysis of Mcl-1in Raji cell lysates with Mcl-1 antibody at (A) 1 and (B) 2 ug/mL.
Immunocytochemistry of Mcl-1 in Raji cells with Mcl-1 antibody at 10 ug/mL.
背景
Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival. While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis and for the development and maintenance of B and T lymphocytes in animals. Mcl-1 exists as at least two distinct isoforms designated Mcl-1L and Mcl-1S. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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400-9961-933
025-58868422

Email Address

techcn@signalwayantibody.com