产品详情
产品名称Acetylsalicylic acid
简述Inhibitors
纯化99.12%
生物活性Aspirin (Acetylsalicylic acid) is a potent and selective inhibitor of cyclooxygenase (COX) with a broad range of pharmacological activities including anti-inflammation and pain relief. Multiple studies have accumulated sufficient evidence to establish the association between the use of aspirin and a reduced risk of Ys including prostate Y, breast Y, colorectal Y, endometrial Y, and ovarian Y. Aspirin suppresses ovarian Y cells harboring COX-1 by acting as histone deacetylase inhibitors to up-regulate cell cycle arrest protein p21. Aspirin also inhibits the expression of COX-2 in human umbilical vein endothelial cells and neonatal rat ventricular cardiomyocytes resulting in reduced PG production and the down-regulation of ERK and NF-KB respectively.
基因/蛋白名称COX inhibitor
CAS号50-78-2
计算分子量180.16
配方C9H8O4
保存3 years -20˚C powder;2 years -80˚C in solvent;
产品描述
Research Area:Nervous system
SMILES:CC(=O)OC1=CC=CC=C1C(O)=O
Pathways:Immunology/Inflammation; Neuroscience
Receptor:COX-1; COX-2
Boling pt:140C
Melting pt:134-136C
Solubility:Ethanol: 36 mg/mL (199.82 mM); DMSO: 36 mg/mL (199.82 mM)
Appearance:White Crystal
Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.
背景文献
1. Kopp E, et al. Science, 1994, 265(5174), 956-959.