产品详情
产品名称Lapatinib ditosylate monohydrate
简述Inhibitors
纯化98.00%
生物活性Lapatinib ditosylate is an anti-Y drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung Y.
基因/蛋白名称EGFR inhibitor
CAS号388082-78-8
计算分子量943.47
配方C29H26ClFN4O4S2(C7H8O3S)H2O
保存3 years -20˚C powder;2 years -80˚C in solvent;
产品描述
Research Area:Cancer
SMILES:O.CC1=CC=C(C=C1)S(O)(=O)=O.CC1=CC=C(C=C1)S(O)(=O)=O.CC1=CC=C(C=C1)S(O)(=O)=O.CC1=CC=C(C=C1)S(O)(=O)=O.CS(=O)(=O)CCNCC1=CC=C(O1)C1=CC2=C(C=C1)N=CN=C2NC1=CC(Cl)=C(OCC2=CC(F)=CC=C2)C=C1.CS(=O)(=O)CCNCC1=CC=C(O1)C1=CC2=C(C=C1)N=CN=C2NC1=CC(Cl)=C(OCC2=CC(F)=CC=C2)C=C1
Pathways:Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Receptor:EGFR; HER2/ErbB2
Boling pt:750.7C
Melting pt:237-239C
Solubility:Soluble in DMSO
Appearance:Colorless or Faint Yellow Crystal
Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.
背景文献
1. Rusnak DW, et al. Mol Y Ther, 2001, 1(2), 85-94.
The lead time is currently 7-30 days.
