产品名称XL184(Cabozantinib malate)

简述Inhibitors

纯化100.00%

生物活性Cabozantinib S-malate is the s-malate salt form of cabozantinib, an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Cabozantinib strongly binds to and inhibits several RTKs, which are often overexpressed in a variety of Y cell types, including hepatocyte growth factor receptor (MET), RET (rearranged during transfection), vascular endothelial growth factor receptor types 1 (VEGFR-1), 2 (VEGFR-2), and 3 (VEGFR-3), mast/stem cell growth factor (KIT), FMS-like tyrosine kinase 3 (FLT-3), TIE-2 (TEK tyrosine kinase, endothelial), tropomyosin-related kinase B (TRKB) and AXL. This may result in an inhibition of both tumor growth and angiogenesis, and eventually lead to tumor regression.

基因/蛋白名称c-Kit inhibitor; c-Met/HGFR inhibitor; TAM Receptor inhibitor; VEGFR inhibitor

CAS号1140909-48-3

计算分子量635.59

配方C32H30FN3O10

保存3 years -20˚C powder;2 years -80˚C in solvent;