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位置: 首页 > 抑制剂 > XL147 analogue

XL147 analogue#S2377

是否有货: The lead time is currently 7-30 days.
产品总价:询价
产品详情

产品名称XL147 analogue

简述Inhibitors

纯化99.72%

生物活性XL147 analogue is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ with IC50 of 39 nM/36 nM/23 nM in cell-free assays, less potent to PI3Kβ. Phase 1/2

基因/蛋白名称DNA-PK inhibitor; PI3K inhibitor

CAS号956958-53-5

计算分子量448.52

配方C21H16N6O2S2

保存3 years -20˚C powder;2 years -80˚C in solvent;

产品描述
Research Area:Cancer
SMILES:CC1=CC=C(C=C1)S(=O)(=O)NC1=NC2=CC=CC=C2N=C1NC1=CC2=NSN=C2C=C1
Pathways:DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
Receptor:DNA-PK; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
Boling pt:
Melting pt:
Solubility:DMSO: 3 mg/mL (6.68 mM)
Appearance:Yellow Powder
Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.
背景文献
1. Chakrabarty A, et al. Proc Natl Acad Sci U S A, 2011, 1-6.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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