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位置: 首页 > 抑制剂 > JNK-IN-8

JNK-IN-8#S2668

是否有货: The lead time is currently 7-30 days.
产品总价:询价
产品详情

产品名称JNK-IN-8

简述Inhibitors

纯化99.50%

生物活性JNK-IN-8 is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK4 with IC50 of 4.7 nM, 18.7 nM and 1 nM, >10-fold selectivity against MNK2, Fms and no inhibition to c-Kit, Met, PDGFRβin A375 cell line.

基因/蛋白名称c-Kit inhibitor; JNK inhibitor

CAS号1410880-22-6

计算分子量507.59

配方C29H29N7O2

保存3 years -20˚C powder;2 years -80˚C in solvent;

产品描述
Research Area:Cancer
SMILES:CC1=C(C=CC(=C1)NC(=O)C2=CC(=CC=C2)NC(=O)/C=C/CN(C)C)NC3=NC=CC(=N3)C4=CN=CC=C4
Pathways:MAPK; Tyrosine Kinase/Adaptors
Receptor:Kit (V559D); Kit (V559D,T670I); JNK1; JNK2; JNK3
Boling pt:
Melting pt:
Solubility:DMSO: 100 mg/mL warmed (197.0 mM)
Appearance:Yellow Powder
Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.
背景文献
1. Zhang T, et al. Chem Biol, 2012, 19(1), 140-154.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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