产品详情
产品名称XL019
简述Inhibitors
纯化99.23%
生物活性XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, exhibiting >50-fold selectivity over JAK1, JAK3 and TYK2. Phase 1.
基因/蛋白名称FLT inhibitor; JAK inhibitor; PDGFR inhibitor
CAS号945755-56-6
计算分子量444.53
配方C25H28N6O2
保存3 years -20˚C powder;2 years -80˚C in solvent;
产品描述
Research Area:Cancer
SMILES:C1C[C@H](NC1)C(=O)NC2=CC=C(C=C2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5
Pathways:Angiogenesis; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors; JAK/STAT signaling; Stem Cells
Receptor:FLT3; JAK1; JAK2; JAK3; PDGFRβ
Boling pt:
Melting pt:
Solubility:DMSO: 16 mg/mL (35.99 mM)
Appearance:Yellow Powder
Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.
背景文献
1. Forsyth T, et al. Bioorg Med Chem Lett, 2012, 22(24), 7653-7658.
The lead time is currently 7-30 days.
