产品详情
产品名称XL388
简述Inhibitors
纯化99.53%
生物活性XL388 is a highly potent, selective, ATP-competitive inhibitor of mTOR with IC50 of 9.9 nM, 1000-fold selectivity over the closely related PI3K kinases.
基因/蛋白名称mTOR inhibitor; P450 inhibitor; PI3K inhibitor
CAS号1251156-08-7
计算分子量455.5
配方C23H22FN3O4S
保存3 years -20˚C powder;2 years -80˚C in solvent;
产品描述
Research Area:Cancer
SMILES:CC1=C(C=CC(=C1F)S(C)(=O)=O)C(=O)N1CCOC2=C(C1)C=C(C=C2)C1=CN=C(N)C=C1
Pathways:Metabolism; PI3K/Akt/mTOR signaling
Receptor:mTOR; mTORC1; mTORC2; CYP2C9; PI3Kα
Boling pt:
Melting pt:
Solubility:DMSO: 23 mg/mL (50.49 mM)
Appearance:
Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.
背景文献
1. Nicole Miller, et al. Mol Y Ther, 2009, 8(12 Suppl):B146.
The lead time is currently 7-30 days.
