产品详情
产品名称YO-01027 (Dibenzazepine)
简述Inhibitors
纯化99.00%
生物活性YO-01027 (Dibenzazepine) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM for APPL and Notch cleavage, respectively.
基因/蛋白名称Gamma-secretase inhibitor
CAS号209984-56-5
计算分子量463.48
配方C26H23F2N3O3
保存3 years -20˚C powder;2 years -80˚C in solvent;
产品描述
Research Area:Others
SMILES:C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)CC4=CC(=CC(=C4)F)F
Pathways:Neuroscience; Proteases/Proteasome; Stem Cells
Receptor:γ secretase (APPL); γ secretase(Notch)
Boling pt:
Melting pt:
Solubility:DMSO:92 mg/mL (198.49 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
Appearance:
Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.
背景文献
1. Groth C, et al, Mol Pharmacol, 2010, 77(4), 567-574.
The lead time is currently 7-30 days.
