产品详情
产品名称PD168393
简述Inhibitors
纯化99.04%
生物活性PD168393 is an irreversible EGFR inhibitor with IC50 of 0.70 nM, irreversibly alkylate Cys-773; inactive against insulin, PDGFR, FGFR and PKC.
基因/蛋白名称EGFR inhibitor; FGFR inhibitor; IGF-1R inhibitor; PDGFR inhibitor; PKC inhibitor
CAS号194423-15-9
计算分子量369.22
配方C17H13BrN4O
保存3 years -20˚C powder;2 years -80˚C in solvent;
产品描述
Research Area:Others
SMILES:BrC1=CC(NC2=NC=NC3=CC=C(NC(=O)C=C)C=C23)=CC=C1 |c:7,21,23,t:1,5,9,11,18|
Pathways:Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors; JAK/STAT signaling
Receptor:EGFR; FGFR; Insulin Receptor; PDGFR; PKC
Boling pt:
Melting pt:
Solubility:Ethanol: <1 mg/mL
DMSO: 74 mg/mL (200.42 mM)
Water: <1 mg/mL (<1 mM)
Appearance:
Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.
背景文献
1. Fry DW,et al. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):12022-7.
The lead time is currently 7-30 days.
