产品详情
产品名称Ulixertinib (BVD-523, VRT752271)
简述Inhibitors
纯化99.00%
生物活性Ulixertinib (BVD-523, VRT752271) is a potent and reversible ERK1/ERK2 inhibitor with IC50 of <0.3 nM for ERK2. Phase 1.
基因/蛋白名称ERK inhibitor
CAS号869886-67-9
计算分子量433.33
配方C21H22Cl2N4O2
保存3 years -20˚C powder;2 years -80˚C in solvent;
产品描述
Research Area:Others
SMILES:CC(C)NC1=NC=C(Cl)C(=C1)C1=CNC(=C1)C(=O)N[C@H](CO)C1=CC(Cl)=CC=C1 |r,c:9,15,27,29,t:4,6,12,24|
Pathways:MAPK
Receptor:ERK2
Boling pt:
Melting pt:
Solubility:Ethanol15 mg/mL (34.61 mM)
DMSO: 86 mg/mL (198.46 mM)
Water: <1 mg/mL
Appearance:
Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.
背景文献
1. Ward RA, et al. J Med Chem. 2015, 58(11), 4790-4801.
The lead time is currently 7-30 days.
