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位置: 首页 > 重组兔单抗 > RASGRP1 Rabbit mAb

RASGRP1 Rabbit mAb#52683

评价
Recombinant
RASGRP1 Rabbit mAb
是否有货: Yes
产品总价:
产品详情

产品名称RASGRP1 Rabbit mAb

来源种属Recombinant Rabbit

克隆性Monoclonal antibody

克隆号S02-2G4

亚型IgG

纯化Affinity Purified

应用WB

种属反应性Human,Mouse

免疫原描述A synthetic peptide of human Rasgrp1

标记Unconjugated

修饰Unmodification

别名V; RASGRP; hRasGRP1; CALDAG-GEFI; CALDAG-GEFII

数据库入口号Swiss-Prot:O95267
GeneID:10125

UniprotO95267

Gene ID10125

计算分子量Calculated MW:90 kDa,Observed MW:90 kDa

配方50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

保存Store at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.

应用详情
WB: 1/1000
Western blot detection of Rasgrp1 in A549,HL-60,U251 cell lysates using Rasgrp1 Rabbit mAb(1:1000 diluted).Predicted band size:90kDa.Observed band size:90kDa.
背景
Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768, PubMed:27776107, PubMed:29155103).Activates the Erk/MAP kinase cascade (PubMed:15899849).Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994, PubMed:27776107, PubMed:29155103).Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860).Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types (PubMed:12845332).

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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