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位置: 首页 > 重组兔单抗 > Phospho-Smad1 (Ser463/Ser465) Rabbit mAb

Phospho-Smad1 (Ser463/Ser465) Rabbit mAb#52702

评价
Recombinant
Phospho-Smad1 (Ser463/Ser465) Rabbit mAb
是否有货: Yes
产品总价:
产品详情

产品名称Phospho-Smad1 (Ser463/Ser465) Rabbit mAb

来源种属Recombinant Rabbit

克隆性Monoclonal antibody

克隆号S07-4A3

亚型IgG

纯化Affinity Purified

应用WB

种属反应性Human,Mouse

免疫原描述A synthetic phosphopeptide corresponding to residues surrounding Ser463/Ser465 of human Smad1

标记Unconjugated

修饰Phosphorylated

别名BSP1; JV41; BSP-1; JV4-1; MADH1; MADR1

数据库入口号Swiss-Prot:Q15797
GeneID:4086

UniprotQ15797

Gene ID4086

计算分子量Calculated MW:52 kDa,Observed MW:52 kDa

配方50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

保存Store at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.

应用详情
WB: 1/1000
Western blot detection of phospho-Smad1 (Ser463/Ser465) in A549,U2OS,C6 cell lysates using phospho-Smad1 (Ser463/Ser465) Rabbit mAb(1:1000 diluted).Predicted band size:52kDa.Observed band size:52kDa.
背景
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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