产品详情
产品名称BMI1 Rabbit mAb
来源种属Recombinant Rabbit
克隆性Monoclonal antibody
克隆号S08-7A6
亚型IgG
纯化Affinity Purified
应用WB
种属反应性Human,Mouse
免疫原描述Recombinant protein of human Bmi1
标记Unconjugated
修饰Unmodification
别名BMI1; PCGF4; RNF51
数据库入口号Swiss-Prot:P35226
GeneID:100532731
UniprotP35226
Gene ID100532731
计算分子量Calculated MW:37 kDa,Observed MW:43 kDa
配方50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
保存Store at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.
应用详情
WB: 1/1000
背景
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373).
The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358).
In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249).
Yes
