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位置: 首页 > 重组兔单抗 > BUBR1 Rabbit mAb

BUBR1 Rabbit mAb#52727

评价
Recombinant
BUBR1 Rabbit mAb
BUBR1 Rabbit mAb
是否有货: Yes
产品总价:
产品详情

产品名称BUBR1 Rabbit mAb

来源种属Recombinant Rabbit

克隆性Monoclonal antibody

克隆号S05-3G7

亚型IgG

纯化Affinity Purified

应用WB IHC

种属反应性Human,Mouse,Rat

免疫原描述A synthetic peptide of human BubR1

标记Unconjugated

修饰Unmodification

别名MVA1; SSK1; BUBR1; Bub1A; MAD3L; hBUBR1; BUB1beta

数据库入口号Swiss-Prot:O60566
GeneID:701

UniprotO60566

Gene ID701

计算分子量Calculated MW:120 kDa,Observed MW:120 kDa

配方50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

保存Store at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.

应用详情
WB: 1/2000-1/10000 IHC: 1/20
Western blot detection of BubR1 in CHO-K1,Ramos cell lysates using BubR1 Rabbit mAb(1:1000 diluted).Predicted band size:120kDa.Observed band size:120kDa.
Immunohistochemistry of BubR1 in paraffin-embedded Human lung cancer tissue using BubR1 Rabbit mAb at dilution 1/50
背景
Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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