产品详情
产品名称HIPK2 Rabbit mAb
来源种属Recombinant Rabbit
克隆性Monoclonal antibody
克隆号S06-5G2
亚型IgG
纯化Affinity Purified
应用WB IF
种属反应性Human,Mouse
免疫原描述A synthetic peptide of human HIPK2
标记Unconjugated
修饰Unmodification
别名PRO0593
数据库入口号Swiss-Prot:Q9H2X6
GeneID:28996
UniprotQ9H2X6
Gene ID28996
计算分子量Calculated MW:131 kDa,Observed MW:131 kDa
配方50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
保存Store at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.
应用详情
WB: 1/2000 ICC/IF: 1/50
背景
Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1.