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位置: 首页 > 重组蛋白 > Recombinant Human/Murine/Rat Activin A

Recombinant Human/Murine/Rat Activin A#AP60131

是否有货: 3-5days
产品总价:
产品详情

产品名称Recombinant Human/Murine/Rat Activin A

来源种属Mammalian Cell

纯化> 95 % by SDS-PAGE analyses.

生物活性Testing in progress.

内毒素Less than 0.01 EU/ug of rHu/Mu/RtActivin A as determined by LAL method.

UniprotP08476

计算分子量Apparent molecular mass of 24 kDa in SDS-PAGE under non-reducing conditions, 14 kDa under reducing conditions, a disulfide-linked homodimer of two 116 amino acid glycosylated polypeptide chains.

配方Lyophilized from a 0.2 um filtered concentrated solution in PBS. 

保存Use a manual defrost freezer and avoid repeated freeze-thaw cycles. - A minimum of 12 months from date of receipt, when stored at ≤-20 ˚C as supplied. - 1 month, 2 to 8 ˚C under sterile conditions after reconstitution. - 3 months, -20 to -70 ˚C under sterile conditions after reconstitution.

背景

Activins and Inhibins are TGF-β superfamily cytokines that are involved in tissue morphogenesis and repair, fibrosis, inflammation, neural development, hematopoiesis, reproductive system function, and carcinogenesis. Activin A protects the heart from hypoxic stress and promotes the differentiation of embryonic stem cells into cardiomyocytes. Activins are homodimers or heterodimers of various β subunits (βA, βB, βC, and βE), while Inhibins are heterodimers of a unique α subunit and one of the β subunits. Activin A is a homodimer of two βA chains. Human βA shares 100% amino acid sequence identity with mouse, rat, bovine, porcine, and feline βA. Activin A binds to Activin RIIA which then associates with Activin RIB/ALK-4. Activin A bioactivity is regulated by cell-associated molecules (BAMBI, Betaglycan, and Cripto) and soluble molecules (β2-Macroglobulin, Follistatin, and FLRG).

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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