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位置: 首页 > 重组蛋白 > Recombinant Human Parathyroid Hormone 1-34

Recombinant Human Parathyroid Hormone 1-34#AP60391

Recombinant Human Parathyroid Hormone 1-34
是否有货: 3-5days
产品总价:
产品详情

产品名称Recombinant Human Parathyroid Hormone 1-34

来源种属Escherichia coli

纯化> 97% by SDS-PAGE and HPLC analyses.

生物活性Fully biologically active when compared to standard. The ED50 as determined by its ability to induce cAMP accumulation in murine MC3T3E1 cells is less than 50 ng/ml, corresponding to a specific activity of > 2.0 x104 IU/mg.

内毒素Less than 1 EU/ug of rHuPTH1-34 as determined by LAL method.

别名Parathormone, Parathyrin

UniprotP01270

Gene ID5741

计算分子量Approximately 4.1 kDa, a single non-glycosylated polypeptide chain containing 34 amino acids.

序列SVSEIQLMHN LGKHLNSMER VEWLRKKLQD VHNF

配方Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.0.

保存Use a manual defrost freezer and avoid repeated freeze-thaw cycles. - A minimum of 12 months from date of receipt, when stored at ≤-20 ˚C as supplied. - 1 month, 2 to 8 ˚C under sterile conditions after reconstitution. - 3 months, -20 to -70 ˚C under sterile conditions after reconstitution.

背景
Parathyroid hormone (PTH) is a single polypeptide of 84 amino acids. PTH is a critical hormone in the regulation of Ca2+ homeostasis. PTH is secreted by the parathyroid glands, which promote release of calcium from bone to extracellular fluid by activating osteoblasts and inhibiting osteoclasts, indirectly promote increased intestinal absorption of calcium, and promote renal tubular reabsorption of calcium and increased renal excretion of phosphates. It is a major regulator of bone metabolism. Secretion of parathyroid hormone increases when the level of calcium in the extracellular fluid is low. The amino terminal (1-34) fragment of parathyroid hormone, called PTH (1-34) reproduces all the activity of the full length mature hormone and has been used therapeutically for treatment of osteoporosis.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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