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Integrin alpha 4 Antibody#24748

Integrin alpha 4 Antibody
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产品总价:
产品详情

产品名称Integrin alpha 4 Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Affinity chromatography purified via peptide column

应用ELISA WB

种属反应性Hu Ms Rt

特异性At least two isoforms are known to exist. The immunogen to this antibody is outside of the Integrin alpha4 recombinant protein fragment and thus will not recognize it.

免疫原类型Peptide

免疫原描述Raised against a 13 amino acid peptide from near the carboxy terminus of human Integrin alpha 4.

基因/蛋白名称Integrin alpha 4

别名CD49d, ITGA4, IA4, alpha 4 subunit of VLA-4 receptor

数据库入口号P13612

UniprotP13612

浓度1mg/ml

配方Supplied in PBS containing 0.02% sodium azide.

保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western blot analysis of Integrin alpha 4 in Jurkat cell lysate with Integrin alpha 4 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
背景
The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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