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位置: 首页 > 磷酸化抗体 > Sufu(Phospho-Ser342) Antibody

Sufu(Phospho-Ser342) Antibody#11552

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产品总价:
产品详情

产品名称Sufu(Phospho-Ser342) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

应用WB

种属反应性Hu

特异性The antibody detects endogenous level of Sufu protein only when phosphorylated at serine 342.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of Serine 342 (A-P-S(p)-R-K) derived from Human Sufu.

基因/蛋白名称Sufu

修饰Phospho

别名SUFUH

数据库入口号Swiss-Prot: Q9UMX1
NCBI Protein: NP_057253.2

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情
Predicted MW: 54kd
Western blotting: 1:500~1:1000
背景
SUFU encodes a component of the Sonic hedgehog (SHH; MIM 600725)/Patched (PTCH; MIM 601309) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes (e.g., HPE3, MIM 142945; BCNS, MIM 109400; and GCPS, MIM 175700)

Zimmern P,et al.(2010) Neurourol Urodyn.29(5):715-8.
Wang C,et al. (2010) Development. 137(12):2001-9.
Rabasseda X.et al.(2010) Drug News Perspect.23(4):273-5.

如果您使用该产品11552发表了文章,请通知我们,让我们可以引用您的文献。

et al,Protein phosphatase 4 promotes Hedgehog signaling through dephosphorylation of Suppressor of fused. In Cell Death Dis on 2020 Aug 11 by Hengqing Liao, Jing Cai, et al..PMID:32826873, , (2020),
PMID: 32826873
et al,Suppressor of Fused (Sufu) Mediates the Effect of Parathyroid Hormone-Like Hormone (Pthlh) on Chondrocyte Differentiation in the Growth Plate.In J Biol Chem on 2012 Oct 19 by Xiaoyun Zhang, Steven Cheng, et al..PMID:22930757, , (2012),
PMID: 22930757
Yan Chen, Shen Yue, Lu Xie et al,Dual Phosphorylation of Suppressor of Fused (Sufu) by PKA and GSK3 b Regulates Its Stability and Localization in the Primary Cilium, THE JOURNAL OF BIOLOGICAL CHEMISTRY, 286(15):13502-13511 (2011),
PMID: 21317289
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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