产品详情
产品名称PKM2(phospho-Ser37) Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
应用WB IF
种属反应性Hu
特异性The antibody detects endogenous level of PKM2 only when phosphorylated at serine 37.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around phosphorylation site of serine 37(I-D-S(p)-P-P) derived from Human PKM2.
基因/蛋白名称PKM2
修饰Phospho
别名PKM, PK3, OIP3, PK2
数据库入口号Swiss-Prot#: P14618 NCBI Protein#: NP_872270.1
UniprotP14618
实际分子量60kd
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C
应用详情
Predicted MW: 60kd
Western Blot: 1:500~1:1000
Immunofluorescence: 1:100~1:200
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et al,ATM inhibition blocks glucose metabolism and amplifies the sensitivity of resistant lung cancer cell lines to oncogene driver inhibitors InCancer MetabOn2023 Nov 6byCristina Terlizzi , Viviana De Rosa et al..PMID:37932830,
, (2023),
PMID: 37932830
et al,Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy,
, (2023),
PMID: 36638784
et al,Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer's disease.In Cell Metab. 2022 Sep 6 by Larissa Traxler 1, Joseph R Herdy,et al..PMID: 35987203,
, (2022),
PMID: 35987203
et al,LncCCAT1 interaction protein PKM2 upregulates SREBP2 phosphorylation to promote osteosarcoma tumorigenesis by enhancing the
Warburg effect and lipogenesis. In Int J Oncol on 2022 Apr by Feifei Pu, Jianxiang Liu,et al..PMID:35244192,
, (2022),
PMID: 35244192
et al,Oncogenic TRIB2 interacts with and regulates PKM2 to promote aerobic glycolysis and lung cancer cell procession. In Cell Death Discov on 2022 Jul 5 by Yuan-Rong Liu, Dan-Dan Song, et al..PMID:35790734,
, (2022),
PMID: 35790734
et al,TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure. In Sci Transl Med
on 2022 Nov 2 by Maria Areli Lorenzana-Carrillo, Keshav Gopal,et al..PMID: 36322626,
, (2022),
PMID: 36322626
et al,Phosphoproteome of signaling by ErbB2 in ovarian cancer cells. In Biochim Biophys Acta Proteins Proteom on 2022 Apr 1 by C Sidhanth, S Bindhya,et al..PMID:35158093,
, (2022),
PMID: 35158093
查看更多
et al,Non-Canonical Role of PDK1 as a Negative Regulator of Apoptosis through Macromolecular Complexes Assembly at the ER锟紺Mitochondria Interface in Oncogene-Driven NSCLC.
In Cancers (Basel) on 2021 Aug 17 by Viviana De Rosa, Francesca Iommelli,et al..PMID:34439291,
, (2021),
PMID: 34439291
et al,Estrogen activates pyruvate kinase M2 and increases the growth of TSC2-deficient cells.In PLoS One on 2020 Feb 20; by Lu Y, Liu X, et al..PMID: 32078667,
, (2020),
PMID: 32078667
et al,Exploring rapamycin-induced pro-survival pathways in Tuberous Sclerosis Complex and the development of alternative therapies,
, (2020),
PMID:
et al,Nuclear translocation of PKM2/AMPK complex sustains cancer stem cell populations under glucose restriction stress.In Cancer Lett. On 2018 May 1 et al..PMID:29408265 ,
, (2018),
PMID: 29408265
et al,Cross-Talk Between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism.In Mol Pharmacol on 2017 Mar by Yannick Audet-Delage,Mich猫le Rouleau,et al..PMID: 28049773,
, (2017),
PMID: 28049773
et al,Glut1 Promotes Cell Proliferation, Migration and Invasion by Regulating Epidermal Growth Factor Receptor and Integrin Signaling in Triple-Negative Breast Cancer Cells.In BMB Rep on 2017 Mar by Sunhwa Oh, Hyungjoo Kim,et al..PMID: 27931517,
, (2017),
PMID: 27931517
et al,Selective GPR55 Antagonism Reduces Chemoresistance in Cancer Cells .In Pharmacol Res on 2016 Sep by Nagendra S Singh , Michel Bernier et al..PMID: 27423937,
, (2016),
PMID: 27423937
et al,Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer.In Oncotarget on 2016 Jul 26 by Oscar Aguilera , Mar铆a Mu帽oz-Sagastibelza et al..PMID:27323830 ,
, (2016),
PMID: 27323830
et al,PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis.In Nat Commun on 2016 Aug 3 by Ji Liang , Ruixiu Cao et al..PMID: 27485204,
, (2016),
PMID: 27485204
et al,ECM1 promotes the Warburg effect through EGF-mediated activation of PKM2.In Cell Signal on 2015 Feb by Kyung-Min Lee, Keesoo Nam et al ..PMID: 25446258,
, (2015),
PMID: 25446258
et al,Estradiol-17尾 Upregulates Pyruvate Kinase M2 Expression to Coactivate Estrogen Receptor-伪 and to Integrate Metabolic Reprogramming With the Mitogenic Response in Endometrial Cells .In J Clin Endocrinol Metab on 2014 Oct by Salama A Salama, Mahmoud A Mohammad et al..PMID:24471565,
, (2014),
PMID: 24471565
et al,ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.In Nat Cell Biol on 2012 Dec by
Weiwei Yang, Yanhua Zheng,et al..PMID:23178880,
, (2012),
PMID: 23178880