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位置: 首页 > 抗体 > TNFRSF6 Antibody

TNFRSF6 Antibody#31015

TNFRSF6 Antibody
是否有货: 有货
产品总价:
产品详情

产品名称TNFRSF6 Antibody

来源种属Rabbit

克隆性Polyclonal

应用ELISA WB

种属反应性Hu

特异性The antibody detects endogenous level of total TNFRSF6 protein.

免疫原类型Recombinant Protein

免疫原描述Fusion protein corresponding to C terminal 180 amino acids of Human Tumor necrosis factor receptor superfamily member 6

基因/蛋白名称TNFRSF6

别名Tumor necrosis factor receptor superfamily member 6, FAS, APT1, CD95, FAS1, APO-1, FASTM, ALPS1A

数据库入口号Genbank No.: BC012479

UniprotBC012479

浓度1.5mg/ml

配方Supplied at 1.1mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.

保存Store at -20˚C/1 year

应用详情

Predicted MW: 38kd
ELISA: 1:500-1:5000
Western blotting: 1:500-1:2000

Gel: 10%+12%SDS-PAGE
Lysate: 40 µg Hela cell lysate
Primary antibody: 1/550 dilution
Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution
Exposure time: 1 minute
背景

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

联系我们

Location :

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Phone :

400-9961-933
025-58868422

Email Address

techcn@signalwayantibody.com