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位置: 首页 > 磷酸化抗体 > Caldesmon (Phospho-Ser789) Antibody

Caldesmon (Phospho-Ser789) Antibody#12012

Caldesmon (Phospho-Ser789) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称Caldesmon (Phospho-Ser789) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB

种属反应性Hu Ms Rt

特异性The antibody detects endogenous level of Caldesmon only when phosphorylated at Serine 789.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of serine 789 (V-T-S(p)-P-T) derived from Human Caldesmon.

基因/蛋白名称Caldesmon

修饰Phospho

别名CDM, HCAD, LCAD, H-CAD, L-CAD

数据库入口号Swiss-Prot#: Q05682;
NCBI Gene#: 800;
NCBI Protein#: NP_004333.1

UniprotQ05682

实际分子量80kd

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C/1 year

应用详情
Predicted MW: 80kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from Rat heart tissue using Caldesmon (Phospho-Ser789) Antibody #12012.The lane on the right is treated with the antigen-specific peptide.
背景
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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