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位置: 首页 > 磷酸化抗体 > ADAM 17 (Phospho-Thr735) Antibody

ADAM 17 (Phospho-Thr735) Antibody#12033

ADAM 17 (Phospho-Thr735) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称ADAM 17 (Phospho-Thr735) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB

种属反应性Hu Ms Rt

特异性The antibody detects endogenous level of ADAM 17 only when phosphorylated at Threonine 735.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of Threonine 735 (P-Q-T(p)-P-G) derived from Human ADAM 17.

基因/蛋白名称ADAM17

修饰Phospho

别名CSVP, TACE, NISBD, ADAM18, CD156B

数据库入口号Swiss-Prot#: P78536;
NCBI Gene#: 6868;
NCBI Protein#: NP_003174.3

UniprotP78536

实际分子量93kd

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C/1 year

应用详情
Predicted MW: 93kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from K562 cells treated with UV using ADAM 17 (Phospho-Thr735) Antibody #12033.The lane on the left is treated with the antigen-specific peptide.
背景
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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025-58868422

Email Address

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