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位置: 首页 > 磷酸化抗体 > HDAC3 (Phospho-Ser424) Antibody

HDAC3 (Phospho-Ser424) Antibody#12045

HDAC3 (Phospho-Ser424) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称HDAC3 (Phospho-Ser424) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB

种属反应性Hu Ms Rt

特异性The antibody detects endogenous level of HDAC3 only when phosphorylated at Serine 424.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of Serine 424 (K-E-S(p)-D-V) derived from Human HDAC3

基因/蛋白名称HDAC3

修饰Phospho

别名HD3, RPD3, RPD3-2

数据库入口号Swiss-Prot#: O15379;
NCBI Gene#: 8841;
NCBI Protein#: NP_003874.2

UniprotO15379

实际分子量48kd

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C/1 year

应用详情
Predicted MW: 48kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from Mouse brain tissue using HDAC3 (Phospho-Ser424) Antibody #12045.The lane on the left is treated with the antigen-specific peptide.
背景
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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025-58868422

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