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位置: 首页 > 抗体 > Cleaved-PARP antibody

Cleaved-PARP antibody#29033

Cleaved-PARP antibody
是否有货: 有货
产品总价:
产品详情

产品名称Cleaved-PARP antibody

来源种属Rabbit

克隆性Polyclonal

纯化Immunogen affinity purified

应用WB

种属反应性Hu Ms

特异性PARP (Cleaved-Asp214) Antibody detects endogenous levels of fragment of activated PARP resulting from cleavage adjacent to Asp214.

基因/蛋白名称Cleaved-PARP

别名ADP-ribosyltransferase 1; ADPRT; ADPRT1; pADPRT-1; PARP; PARP-1; poly (ADP-ribose) pol; poly [ADP-ribose] polymerase 1; poly[ADP-ribose] synthetase 1; PPOL

数据库入口号Swiss-Prot#: P09874

UniprotP09874

实际分子量85,110KD

浓度1.0mg/ml

配方Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 14 months from date of receipt

保存Store at -20°C/1 year

应用详情

 WB: 1:500-1:2000

Western blot analysis of extracts from A549 cells,The lane on the left is treated with the antigen-specific peptide.
背景

 Nvolved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.

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et al,The effect of ibrutinib on radiosensitivity in pancreatic cancer cells by targeting EGFR/AKT/mTOR signaling pathway. In Biomed Pharmacother on 2020 Aug by Biqin Tan, Yuyu Huang, et al..PMID:32447207, , (2020),
PMID: 32447207
et al,Apicidin Inhibited Proliferation and Invasion and Induced Apoptosis via Mitochondrial Pathway in Non-small Cell Lung Cancer GLC-82 Cells.Anticancer Agents Med Chem on 2017 by Jianye Zhang , Zhenzhu Lai,et al..PMID: 28425856, , (2017),
PMID: 28425856
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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