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位置: 首页 > 单克隆抗体 > Smad2 Monoclonal Antibody

Smad2 Monoclonal Antibody#27195

Smad2 Monoclonal Antibody
Smad2 Monoclonal Antibody
是否有货: 有货
产品总价:
产品详情

产品名称Smad2 Monoclonal Antibody

来源种属Mouse

克隆性Monoclonal

克隆号6H5-E3-C11

亚型IgG1

应用WB ICC

种属反应性Hu

特异性This antibody detects endogenous levels of SMAD2 and does not cross-react with related proteins.

免疫原类型Recombinant Protein

免疫原描述Purified recombinant human SMAD2 protein fragments expressed in E.coli.

基因/蛋白名称Smad2

别名hMAD 2; hMAD-2; hSMAD2; JV18 1; JV18; JV18; JV18-1; JV181; MAD; MAD; MAD homolog 2; MAD Related Protein 2; Mad-related protein 2; MADH2; MADR2; MGC22139; MGC34440; Mothers Against Decapentaplegic Homolog 2; Mothers Against Decapentaplegic Homolog 2;

数据库入口号Uniprot: Q15796

Gene ID: 4087

UniprotQ15796

实际分子量60kd

配方ascites

保存store at -20˚C

应用详情

Western blotting: 1:500

Immunocytochemistry: 1:100
Immunocytochemistry staining of HeLa cells fixed with 1% Paraformaldehyde and using anti-SMAD2 antibody (dilution 1:100).
Western blot detection of SMAD2 antibody in Hela,A431,Jurkat and K562 cell lysates using SMAD2 antibody (1:500 diluted).Predicted band size:60KDa.Observed band size:60KDa.
背景

 Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases.Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and,on formation of the SMAD2/SMAD4 complex,activates transcription.May act as a tumor suppressor in colorectal carcinoma.Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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