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位置: 首页 > 磷酸化抗体 > Trk A (Phospho-Tyr680/681) Antibody

Trk A (Phospho-Tyr680/681) Antibody#11904

Trk A (Phospho-Tyr680/681) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称Trk A (Phospho-Tyr680/681) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB

种属反应性Hu Ms Rt

特异性The antibody detects endogenous level of Trk A only when phosphorylated at tyrosine 680/tyrosine 681.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of tyrosine 680/tyrosine 681 (T-D-Y(p)-Y(p)-R-V) derived from Human Trk A.

基因/蛋白名称Trk A

修饰Phospho

别名High affinity nerve growth factor receptor precursor; NTRK1; Slow nerve growth; TRK; Trk-A

数据库入口号Swiss-Prot#: P04629;
NCBI Gene#: 4914;
NCBI Protein#: NP_001007793.1

UniprotP04629

实际分子量87kd

浓度1.0mg/ml

配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C/1 year

应用详情
Western blotting: 1:500~1:1000
Western blot analysis of extracts from Jurkat cells treated with starved using Phospho-Trk A (Tyr680/Tyr681) antibody #11904.The lane on the right is treated with the antigen-specific peptide.
背景

Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.

Liu HY, et al. (2005) J Biol Chem 280, 19461-71
Wahab NA, Weston BS, Mason RM (2005) J Am Soc Nephrol 16, 340-51
Marsh HN, et al. (2003) J Cell Biol 163, 999-1010

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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