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位置: 首页 > 磷酸化抗体 > CD44 (Phospho-Ser706) Antibody

CD44 (Phospho-Ser706) Antibody#11911

CD44 (Phospho-Ser706) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称CD44 (Phospho-Ser706) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB

种属反应性Hu Ms Rt

特异性The antibody detects endogenous level of CD44 only when phosphorylated at serine 706.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of serine 706 (S-K-S(p)-Q-E) derived from Human CD44.

基因/蛋白名称CD44

修饰Phospho

别名CD44 antigen precursor; ECMR-III; Epican; Hermes antigen; PGP-1

数据库入口号Swiss-Prot#: P16070;
NCBI Gene#: 960;
NCBI Protein#: NP_000601.3

UniprotP16070

实际分子量81 90 kd

浓度1.0mg/ml

配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C/1 year

应用详情
Western blotting: 1:500~1:1000
Western blot analysis of extracts from NIH-3T3 cells treated with PMA using Phospho-CD44 (Ser706) antibody #11911.The lane on the right is treated with the antigen-specific peptide.
背景

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.

Ildefonso CJ, et al. (2012)J Biol Chem 287, 32697-707. Pivetta E, et al. (2011)J Cell Physiol 226, 769-79. Wang YT, et al. (2010)J Proteome Res 9, 5582-97.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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