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位置: 首页 > 磷酸化抗体 > ATF1 (Phospho-Ser63) Antibody

ATF1 (Phospho-Ser63) Antibody#11913

ATF1 (Phospho-Ser63) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称ATF1 (Phospho-Ser63) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB

种属反应性Hu Ms

特异性The antibody detects endogenous level of ATF1 only when phosphorylated at serine 63.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of serine 63(R-P-S(p)-Y-R) derived from Human ATF1 .

基因/蛋白名称ATF1

修饰Phospho

别名ATF1; Activating transcription factor 1; Cyclic-AMP-dependent transcription factor ATF-1; TCR-ATF1; TREB36 protein

数据库入口号Swiss-Prot#: P18846;
NCBI Gene#: 466;
NCBI Protein#: NP_005162.1

UniprotP18846

实际分子量29kd

浓度1.0mg/ml

配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C/1 year

应用详情
Western blotting: 1:500~1:1000
Western blot analysis of extracts from HT29 cells treated with Insulin using Phospho-ATF1 (Ser63) antibody #11913.The lane on the right is treated with the antigen-specific peptide.
背景

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.

Mackenzie KF, et al. (2013) J Immunol 190, 565-77
Dickinson RJ, et al. (2011) J Biol Chem 286, 38018-26
Wang J, Zhou JY, Wu GS (2011) J Biol Chem 286, 22384-92

如果您使用该产品11913发表了文章,请通知我们,让我们可以引用您的文献。

5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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