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位置: 首页 > 磷酸化抗体 > SirT1 (Phospho-Ser47) Antibody

SirT1 (Phospho-Ser47) Antibody#11926

SirT1 (Phospho-Ser47) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称SirT1 (Phospho-Ser47) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB

种属反应性Hu

特异性The antibody detects endogenous level of SirT1 only when phosphorylated at serine 47.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of serine 47(E-R-S(p)-P-G) derived from Human SirT1.

基因/蛋白名称SirT1

修饰Phospho

别名hSIR2; hSIRT1; NAD-dependent deacetylase sirtuin 1; SIR1; SIR2L1

数据库入口号Swiss-Prot#: Q96EB6;
NCBI Gene#: 23411;
NCBI Protein#: NP_001135970.1

UniprotQ96EB6

实际分子量110kd

浓度1.0mg/ml

配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C/1 year

应用详情
Western blotting: 1:500~1:1000
Western blot analysis of extracts from JK tissue using SirT1 (Phospho-Ser47) antibody #11926.The lane on the right is treated with the antigen-specific peptide.
背景

NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively.

Gao Z, et al. (2011) J Biol Chem 286, 22227-34. Zschoernig B, Mahlknecht U (2009)Biochem Biophys Res Commun 381, 372-7. Nasrin N, et al. (2009)PLoS One 4, e8414.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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